Will the Layla Mattress work on an adjustable base? Layla August 20, 2020 19:10 Updated Follow Yes. The Layla Mattress is an ideal choice for an adjustable base conforms perfectly in all adjustable positions. Related articles What Base or Foundation can I use with the Layla Mattress? Can I use a Mattress Protector or additional cover with the Layla Mattress? How do I unbox the Layla Mattress? What are the Layla Mattress Lifetime Warranty Details? Can I wash the Mattress Cover? Comments 0 comments Please sign in to leave a comment.