Will the Layla Mattress work on an adjustable base? Layla March 09, 2021 19:36 Updated Follow Yes. The Layla® Mattress is an ideal choice for an adjustable base conforms perfectly in all adjustable positions. Related articles What Base or Foundation can I use with the Layla Mattress? How do I flip the Layla Mattress from the soft side to the firm side? How do I unbox the Layla® Mattress? Will the Layla Hybrid™ Mattress Work with an Adjustable Base? How often should I rotate the Layla® Mattress? Comments 0 comments Please sign in to leave a comment.